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Histopathologic vertical margin positivity in cold snare polypectomy and mucosal resection for sessile serrated lesions

2024.08.16

Author: Koichi Hamada, Michitaka Honda, Yoshinori Horikawa,

Yoshiki Shiwa, Kae Techigawara, Takayuki Nagahashi, Masafumi Ishikawa, Yuki Takeda, Daizo Fukushima, Noriyuki Nishino, Noriyuki Uesugi, Masamichi Suzuki, Tamotsu Sugai

Background and Aims

Data regarding the status of the vertical margin of sessile serrated lesions (SSLs) resected using cold snare polypectomy (CSP) are lacking, and whether a histopathologically positive vertical margin is related to recurrence remains unclear. Therefore, this preliminary study aimed to clarify the rates of positive or unassessable vertical and horizontal margins and the rate of muscularis mucosae resection in SSLs treated using CSP compared with those treated with EMR.

Methods

Overall, 82 patients with SSLs were included in the CSP and EMR groups after matching. The incidence of positive histologic vertical margins in the CSP and EMR groups were 67.1% and 2.4%, respectively (P < .001). Regarding the evaluation of the presence of muscularis mucosae, 29.3% and 98.8% of patients in the CSP and EMR groups, respectively, had a complete muscularis mucosae resection (P < .001).

Results

Histologic outcomes of patients treated with CSP or EMR for SSLs were evaluated in this single-center observational study. The primary outcome was the incidence of histopathologically positive vertical margins in CSP and EMR. Furthermore, the comparisons were adjusted for confounding factors using propensity score matching.

Conclusions

A rigorous histopathologic evaluation revealed that for SSLs, CSP more frequently leads to positive vertical margins than EMR. (Clinical trial registration number: UMIN 000051569.)

https://www.sciencedirect.com/science/article/abs/pii/S0016510724000440

*The above content is sourced from Google Scholar. This article is for academic sharing and learning purposes only.

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